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Research

Multivitamins

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By: Sean Moloughney

Editor, Nutraceuticals World

Indication: Cardiovascular disease and diabetes

Source: Am J Med, December 15, 2003;115(9):702-7.

Research: The study examined whether multivitamins reduce C-reactive protein (CRP) levels, which are associated with the risk of cardiovascular disease and diabetes. Researchers performed a post hoc subgroup analysis of a six-month, randomized, double-blind, placebo-controlled trial. Patients for whom frozen plasma samples were available who did not have an inflammatory condition at baseline and who were not hospitalized, taking antibiotics, smoking or starting statin therapy during the study were included. C-reactive protein and plasma vitamin levels were measured at baseline and six months.

Results: At six months, C-reactive protein levels were significantly lower in the multivitamin group than in the placebo group. The reduction in C-reactive protein levels was most evident in patients who had elevated levels at baseline. Of the six vitamins measured (C, E, B6, B12, folate and beta carotene), only vitamin B6 and vitamin C were inversely associated with C-reactive protein levels.

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